Antifungal Activity of Some Extracts Supplemented with Silver Nanoparticles

Abstract Background: Turmeric has long been used in traditional medicine, thanks to its multiple healing properties. Objectives: This study seeks to evaluate the effectiveness of various turmeric extracts, including those enhanced with silver nanoparticles (AgNPs), in combating the common skin fungi Trichophyton mentagrophytes and Trichophyton rubrum . Materials and Methods: Nutrient media containing different concentrations (5, 10, 15, and 20 mg/mL) of turmeric extracts were used to evaluate their inhibitory effects on fungal growth. Minimum inhibitory concentrations have been determined for each type of extract. Results: Both aqueous and alcoholic turmeric extracts have shown antifungal activity against both fungal species. However, T. rubrum has been found to be more sensitive to T. mentagrophytes . The addition of AgNPs to the aqueous extract significantly enhanced the antifungal activity. Conclusion: The study showed that turmeric extracts have promising antifungal activity, especially against T. rubrum . These results encourage further research into developing effective and safe natural medicines for the treatment of fungal infections while understanding the molecular mechanisms behind this effect.