The Fate of Zona free Oocyte Following Intracytoplasmic Sperm Injection: A Case Report and Review of Literature
The zona pellucida (ZP) is essential in reproductive biology, covering sperm selection, species-specific fertilisation, inhibition of polyspermy and stability of blastomeres in embryos. This case report highlights the developmental potential of a zona-free oocyte (ZFO). A 44-year-old woman produced a single oocyte, where detachment of the ZP occurred during the denudation process, leaving a ZFO. This oocyte underwent intracytoplasmic sperm injection (ICSI) and subsequent culture, developing into a four-cell embryo on the 3<sup>rd</sup> day. Despite embryo transfer, no pregnancy was achieved 14 days post-transfer. This case underlines the potential for cell development in ZFOs while emphasising the challenges of achieving successful implantation.
Authors
- Geraldo Laurus (ORCID: https://orcid.org/0000-0002-4232-4797)
- Zakiyatul Faizah (ORCID: https://orcid.org/0000-0003-0962-9123)
- Hendy Hendarto (ORCID: https://orcid.org/0000-0001-5551-2028)
- Vellyana Lie (ORCID: https://orcid.org/0000-0001-5169-7598)
Institutions
- Universitas Airlangga (ID)
- Universitas Dr. Soetomo (ID)
Publication Details
- Journal
- Journal of Human Reproductive Sciences
- Published
- 2025-01-01
- DOI
- https://doi.org/10.4103/jhrs.jhrs_174_24
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universitas Airlangga