CD147 inhibition reduced fibronectin expression in TGF-β1-induced keloid fibroblasts by targeting Smad2 signaling pathway
These findings suggest that CD147 is closely involved in keloid progression. Inhibition of CD147 downregulates TGF-β1-induced fibronectin expression in KFs by targeting Smad2 signaling pathway. Thus, CD147 may serve as a promising therapeutic target for keloid treatment.
Authors
- Huicong Du
- Jian‐Sheng Diao (ORCID: https://orcid.org/0009-0002-4566-6204)
- Raymond Lai (ORCID: https://orcid.org/0000-0002-6963-2407)
- Muneeb Ur Rahman (ORCID: https://orcid.org/0009-0009-7924-9194)
- Juan Wu (ORCID: https://orcid.org/0000-0001-6554-8921)
- Xiuguo Han (ORCID: https://orcid.org/0000-0001-5787-5332)
- Menglu Wu (ORCID: https://orcid.org/0009-0002-5742-2231)
- Maoguo Shu (ORCID: https://orcid.org/0000-0002-3412-0209)
Institutions
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Burns
- Published
- 2025-03-30
- DOI
- https://doi.org/10.1016/j.burns.2025.107472
- Citations
- 5
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.13
Funders
- National Natural Science Foundation of China