Coronavirus Disease 2019 Symptoms by Immunity Status and Predominant-Variant Period Among US Blood Donors
Our data suggest that both prior immunity and Omicron predominance redistributed COVID-19 symptoms toward upper respiratory tract presentations and likely both contributed to a decrease in COVID-19 severity over time. These findings may better inform COVID-19 identification in high-immunity settings and demonstrate additional benefits of vaccination.
Authors
- Jefferson M. Jones (ORCID: https://orcid.org/0000-0003-4974-9058)
- Melissa Briggs Hagen (ORCID: https://orcid.org/0000-0001-7359-9665)
- Claire M. Midgley (ORCID: https://orcid.org/0000-0001-5196-4713)
- Matthew D McCullough (ORCID: https://orcid.org/0000-0003-1079-2024)
- Bryan R. Spencer (ORCID: https://orcid.org/0000-0002-9008-9154)
- Melisa M. Shah (ORCID: https://orcid.org/0000-0002-7277-1547)
- Ian D. Plumb (ORCID: https://orcid.org/0000-0003-4747-381X)
- Susan L. Stramer (ORCID: https://orcid.org/0000-0002-5865-6366)
- James M. Haynes
- Jianrong Shi (ORCID: https://orcid.org/0009-0002-7323-0504)
Institutions
- Centers for Disease Control and Prevention (US)
- American Red Cross (US)
- National Center for Immunization and Respiratory Diseases (US)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1093/ofid/ofaf185
- Citations
- 1
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- American Red Cross
- Centers for Disease Control and Prevention