The impact of a selective androgen receptor modulator (RAD140) on frailty and underlying mechanisms in older male and female C57Bl/6 mice
Six-weeks of RAD140 treatment did not affect frailty in older male or female mice. The beneficial effects in lean mass, bone mineral density, and systemic inflammation warrant longer treatments to explore any positive impact on frailty in males. RAD140 may not be ideal for achieving these in females.
Authors
- Stefan Heinze-Milne (ORCID: https://orcid.org/0000-0002-5373-7685)
- Marilyn J. Hodgins (ORCID: https://orcid.org/0000-0002-7920-3315)
- Susan E. Howlett (ORCID: https://orcid.org/0000-0001-5351-6308)
Institutions
- Dalhousie University (CA)
Publication Details
- Journal
- Mechanisms of Ageing and Development
- Published
- 2025-03-30
- DOI
- https://doi.org/10.1016/j.mad.2025.112054
- Citations
- 2
- Primary Topic
- Hormonal and reproductive studies
- Type
- article
- Field-Weighted Citation Impact
- 2.59