High Acceptability but Persistent Barriers to Implementation of Long-acting Injectable Antiretrovirals: A Nationwide Cross-sectional Survey of Ryan White Clinics in the United States

Despite high acceptability and appropriateness, clinics' perceived feasibility of LAI ART implementation was low. Barriers to implementation include nonstandardization of prior authorizations, obtaining the medication, and cost of implementation. Clinics with a larger Medicaid-insured population reported higher acceptability and appropriateness of LAI ART, suggesting that public insurance might promote equitable access. Interventions that address structural barriers are needed to improve uptake.