Glycoproteomics of IgA1: uncovering key <i>N</i>-glycan composition in ankylosing spondylitis
IgA1 from patients with AS exhibited distinct glycosylation traits compared with controls, with elevated levels of HexNAc₄Hex₄NeuAc₁ at N144 associated with inflammatory markers. These findings suggested that differential glycosylation patterns of IgA1 may play a role in the pathogenesis of AS.
Authors
- Kuo-Lung Ku
- Ning‐Sheng Lai (ORCID: https://orcid.org/0000-0001-6853-7451)
- Kuang‐Yung Huang (ORCID: https://orcid.org/0000-0001-8399-6226)
- Chien‐Hsueh Tung (ORCID: https://orcid.org/0000-0003-1234-6263)
- Hui‐Ling Chiang
- Ming‐Chi Lu (ORCID: https://orcid.org/0000-0001-9051-0351)
Institutions
- National Chiayi University (TW)
- Tzu Chi University (TW)
- Tzu Chi Foundation (TW)
- Buddhist Tzu Chi Medical Foundation (US)
Publication Details
- Journal
- Glycobiology
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1093/glycob/cwaf018
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00