Angioleiomyoma of cheek – A case report highlighting immunohistochemical diagnostic approach

Benign smooth muscle tumours, known as leiomyomas, are comparatively frequent, with uterine cases accounting for 95% incidence. Oral leiomyomas typically appear as asymptomatic, slowly-growing submucosal lumps in the tongue, hard palate, or buccal mucosa. Three histologic kinds of leiomyomas are recognized: epithelioid leiomyoma, solid leiomyoma, and angioleiomyoma. The most prevalent type of leiomyomas affecting the oral cavity are solitary forms called angioleiomyomas, which typically develop in the subcutis. The diagnosis is commonly determined by histopathological and Immunohistochemistry (IHC) procedures. This case reports a 30-year-old female patient with a lesion on her right cheek region. The postsurgical specimen was routinely processed and stained with hematoxylin and eosin staining, and IHC studies confirmed the diagnosis of 'Benign spindle cell neoplasm-Angioleiomyoma'.