Unravelling a solitary gingival swelling: A unique case report of clear cell calcifying epithelial odontogenic tumour

Gingiva is one of the common sites for many reactive, benign and malignant lesions. Localized gingival overgrowths usually present with a wide variety of clinical and histopathological features, and it will create a challenge for proper diagnosis. We report a case of a 48-year-old male patient with a slow-growing swelling on the lower anterior gingiva, extending to the floor of the mouth. A differential diagnosis of pyogenic granuloma or salivary gland neoplasm was considered. The lesion was diagnosed as clear cell variant of calcifying epithelial odontogenic tumour after the histopathological and immunohistochemical evaluation of multiple biopsy specimens from different sites of the lesion. Clear cell variant of calcifying epithelial odontogenic tumour is a very rare, aggressive variant of CEOT which demands proper clinicopathologic and radiographic examination for diagnosis. It also highlights the necessity for multiple biopsies in case of larger gingival lesions.