Integrating Aggregate Materials and Machine Learning Algorithms: Advancing Detection of Pathogen‐Derived Extracellular Vesicles
ABSTRACT Extracellular vesicles (EVs) are essential for host–pathogen interactions, mediating processes such as immune modulation and pathogen survival. Pathogen‐derived EVs hold significant diagnostic potential because of their unique cargo, offering a wealth of potential biomarkers. In this review, we first discuss the roles of EVs derived from various pathogens in host–pathogen interactions and summarize the latest advancements in pathogen detection based on EVs. Then, we highlight innovative strategies, including novel aggregate materials and machine learning approaches, for enhancing EV detection and analysis. Finally, we discuss challenges in the field and future directions for advancing EV‐based diagnostics, aiming to translate these insights into clinical applications.
Authors
- Zehong Peng (ORCID: https://orcid.org/0000-0003-0495-1834)
- Tony Y. Hu (ORCID: https://orcid.org/0000-0002-5166-4937)
- Wei Xue (ORCID: https://orcid.org/0000-0003-0124-9433)
- Liang Fei Dong (ORCID: https://orcid.org/0000-0001-6118-3697)
- Cong Hu (ORCID: https://orcid.org/0000-0002-5309-5985)
- Lai Li (ORCID: https://orcid.org/0000-0003-2336-3202)
- Yun Su (ORCID: https://orcid.org/0000-0003-1286-7050)
Institutions
- Tulane University (US)
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Shanghai Ninth People's Hospital (CN)
Publication Details
- Journal
- Aggregate
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1002/agt2.70018
- Citations
- 3
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Cancer Institute
- National Institute of Allergy and Infectious Diseases
- National Institute of Neurological Disorders and Stroke
- Eunice Kennedy Shriver National Institute of Child Health and Human Development