Despite adverse event risk, anti psychotic polypharmacy has continued to rise

Concurrent use of two or more anti­psychotics has continued to increase over the past 50 years despite its association with a higher risk of adverse events, a systematic review and meta‐analysis has found. In comparison with anti­psychotic monotherapy, polypharmacy was associated with higher risk of adverse outcomes such as relapse and psychiatric hospitalization. Results of the review and meta‐analysis were published online Nov. 12, 2024, in Lancet Psychiatry .

Publication Details

Journal
The Brown University Psychopharmacology Update
Published
2025-03-27
DOI
https://doi.org/10.1002/pu.31298
Primary Topic
Pharmaceutical Practices and Patient Outcomes
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Despite adverse event risk, anti psychotic polypharmacy has continued to rise

The Brown University Psychopharmacology Update
Pharmaceutical Practices and Patient Outcomes
article

Despite adverse event risk, anti psychotic polypharmacy has continued to rise

article en

Abstract

Concurrent use of two or more anti­psychotics has continued to increase over the past 50 years despite its association with a higher risk of adverse events, a systematic review and meta‐analysis has found. In comparison with anti­psychotic monotherapy, polypharmacy was associated with higher risk of adverse outcomes such as relapse and psychiatric hospitalization. Results of the review and meta‐analysis were published online Nov. 12, 2024, in Lancet Psychiatry .

The Brown University Psychopharmacology UpdateVol. 36(5)
Openalex Percentile: Top 92%
Pharmaceutical Practices and Patient Outcomes
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Despite adverse event risk, anti psychotic polypharmacy has continued to rise · The Brown University Psychopharmacology Update (2025) | TGRS Research Map | TGRS