Psilocybin‐assisted therapy leads to personality shifts in patients with alcohol use disorder

Adults with alcohol use disorder who received two sessions of psilocybin‐assisted therapy demonstrated personality shifts toward normalization of abnormal trait expression, a secondary analysis of a randomized trial has found. A decrease in impulsiveness was found to be associated with reduced drinking post‐treatment, with the strongest effect for psilocybin‐treated individuals who had engaged in moderate‐ or high‐risk drinking before treatment.

Publication Details

Journal
The Brown University Psychopharmacology Update
Published
2025-03-27
DOI
https://doi.org/10.1002/pu.31300
Primary Topic
Psychedelics and Drug Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Psilocybin‐assisted therapy leads to personality shifts in patients with alcohol use disorder

The Brown University Psychopharmacology Update
Psychedelics and Drug Studies
article

Psilocybin‐assisted therapy leads to personality shifts in patients with alcohol use disorder

article en

Abstract

Adults with alcohol use disorder who received two sessions of psilocybin‐assisted therapy demonstrated personality shifts toward normalization of abnormal trait expression, a secondary analysis of a randomized trial has found. A decrease in impulsiveness was found to be associated with reduced drinking post‐treatment, with the strongest effect for psilocybin‐treated individuals who had engaged in moderate‐ or high‐risk drinking before treatment.

The Brown University Psychopharmacology UpdateVol. 36(5)
Openalex Percentile: Top 91%
Psychedelics and Drug Studies
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Psilocybin‐assisted therapy leads to personality shifts in patients with alcohol use disorder · The Brown University Psychopharmacology Update (2025) | TGRS Research Map | TGRS