Not Indolamine 2,3-Dioxygenase Polymorphisms, but Low Levels of Indoleamine 2,3-Dioxygenase and IDO2 Are Associated with Behçet’s Syndrome
Our research revealed that the serum IDO/IDO2 levels of BS were substantially lower than those in the control group. This finding has the potential to impact IDO activity and reduce immune tolerance. No correlation was observed between IDO/IDO2 polymorphisms and most clinical findings of BS. However, the IDO rs7820268 CT genotype was significantly reduced in neuro-BS, suggesting a protective effect. Larger prospective trials are needed to further explore these findings. .
Authors
- Ülkü Uçar (ORCID: https://orcid.org/0000-0003-4838-1650)
- Yağmur Aydın Atalay
- Güven Özkaya (ORCID: https://orcid.org/0000-0003-0297-846X)
- Haluk Barbaros Oral (ORCID: https://orcid.org/0000-0003-0463-6818)
Institutions
- Bursa Uludağ Üni̇versi̇tesi̇ (TR)
- Antalya Eğitim ve Araştırma Hastanesi (TR)
Publication Details
- Journal
- Medical Principles and Practice
- Published
- 2025-03-29
- DOI
- https://doi.org/10.1159/000545581
- Citations
- 2
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.16