Correlation between Endothelin-1 Levels and Mean Arterial Pressure (MAP) in Pregnant Women with Preeclampsia

Introduction: Preeclampsia is a common obstetric complication worldwide associated with maternal and perinatal morbidity and mortality. Hypertensive disorders of pregnancy (HDP) are characterized by high blood pressure and proteinuria after the 20th week of gestation which can result in eclampsia and multiple organ failure. The increased release of ET-1 in preeclampsia may have vascular constrictor effects and therefore the high concentration of ET-1 may be related to hypertension, because ET-1 is a potent vasoconstrictor. Estimation of association between ET-1 and mean arterial pressure (MAP) would aid in defining the predictions for further progress of the preeclamptic women into severe disease. Method: This study is an analytic correlational study carried out at the Prof. Dr. I. G. N. G. Ngoerah Hospital, Denpasar, with subjects of pregnant women with preeclampsia who met the inclusion criteria. MAP was recorded and the serum samples were collected for ET-1 level measurement with the ELISA method. A consecutive sampling method was used to achieve a sample size of 50 participants. Results: The study found a significant positive correlation between ET-1 levels and MAP in preeclamptic subjects, suggesting that ET-1 elevation isassociated with increased MAP, further supporting the role of ET-1 in the pathophysiology of preeclampsia-related hypertension. Conclusion: ET-1 levels correlate positively with MAP, indicating a potential diagnostic marker for preeclampsia progression.