Intestinal dysbiosis alters acute seizure burden and antiseizure medicine activity in Theiler's virus model of encephalitis
ABX-induced gut dysbiosis markedly altered acute disease trajectory with TMEV-induced encephalitis, reflecting a novel contribution of the gut microbiome to seizure presentation. ABX-induced gut dysbiosis also significantly changed acute seizure control by CBZ, but did not influence plasma CBZ concentrations. The gut-brain axis is thus an underrecognized contributor to TMEV infection-induced seizures, ASM activity, and disease burden.
Authors
- Kenneth E. Thummel (ORCID: https://orcid.org/0000-0002-7799-3739)
- Melissa Barker‐Haliski (ORCID: https://orcid.org/0000-0002-8175-0553)
- Stephanie Davidson
- Aaron C. Ericsson (ORCID: https://orcid.org/0000-0002-3053-7269)
- Hanna Choi (ORCID: https://orcid.org/0000-0003-4966-5321)
- Michelle Guignet (ORCID: https://orcid.org/0000-0003-4788-0175)
- Kristen Peagler
- Inga Erickson
- S Rho
Institutions
- University of Washington (US)
- University of Missouri (US)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1111/epi.18395
- Citations
- 3
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.73
Funders
- University of Washington