An Overview of Isavuconazole Clinical Use: A Multicentre Analysis of Indications, Exposure and Hepatic Safety
This multicentre analysis highlighted the common use of isavuconazole as an off-label indication, as well as the frequent underexposure of patients to isavuconazole. Albumin on the day of TDM appeared to be an important factor driving isavuconazole exposure, especially in ICU patients.
Authors
- Pauline Rascle
- Anne‐Lise Bienvenu (ORCID: https://orcid.org/0000-0003-1502-1851)
- François Parant (ORCID: https://orcid.org/0000-0002-4019-532X)
- L. Foroni
- Claire Chatron
- Cécile Moluçon‐Chabrot (ORCID: https://orcid.org/0000-0003-1948-5258)
- Aurélien Millet
- Philippe Portran (ORCID: https://orcid.org/0000-0002-7640-2642)
- Pierre Pradat (ORCID: https://orcid.org/0000-0001-6331-8321)
- Thierry Vial (ORCID: https://orcid.org/0000-0003-3786-581X)
- Sylvain Goutelle (ORCID: https://orcid.org/0000-0002-1853-2932)
- Hélène Labussière‐Wallet (ORCID: https://orcid.org/0000-0003-0543-9592)
- Alexandra Duffour
- Anne‐Claire Lukaszewicz
- Agnès Henry
- Natacha Mrozek (ORCID: https://orcid.org/0000-0002-8632-4967)
- Claire Merveilleux-du-Vignaux
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Centre National de la Recherche Scientifique (FR)
- Lyon College (US)
- Hôpital de la Croix-Rousse (FR)
- Hospices Civils de Lyon (FR)
- University of Clermont Auvergne (FR)
- Archéologie et Archéométrie (FR)
- Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
- Laboratoire de Biométrie et Biologie Evolutive (FR)
Publication Details
- Journal
- Clinical Drug Investigation
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1007/s40261-025-01432-z
- Citations
- 4
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 5.58
Funders
- Hospices Civils de Lyon
- Centre Hospitalier Universitaire de Clermont-Ferrand