NEK2 promotes cancer cell progression and 5-fluorouracil resistance via the Wnt/β-catenin signaling pathway in colorectal cancer
In summary, NEK2 promotes cell survival and decreases sensitivity to 5-FU in CRC by activating the Wnt/β-catenin signaling pathway. Consequently, NEK2 holds promise as a potential therapeutic target for CRC management.
Authors
- Weifeng Zhao (ORCID: https://orcid.org/0000-0001-5905-1396)
- Xiaoyu Wu (ORCID: https://orcid.org/0000-0003-3376-5643)
- Facai Cui (ORCID: https://orcid.org/0009-0005-7858-6456)
- Yu Chen (ORCID: https://orcid.org/0000-0002-4717-9066)
Institutions
- Zhengzhou University (CN)
- Henan Provincial People's Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1007/s12672-025-02154-6
- Citations
- 2
- Primary Topic
- Wnt/β-catenin signaling in development and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61