Metformin ameliorates osteoporosis by enhancing bone angiogenesis via the YAP1/TAZ-HIF1α axis
Our findings suggest that metformin holds promise as a therapeutic agent for osteoporosis by enhancing type H vessel formation through the inhibition of the YAP1/TAZ-HIF1α axis.
Authors
- Tengfei Wan (ORCID: https://orcid.org/0000-0002-0273-3721)
- Jingtao Zou
- Yong Zhu (ORCID: https://orcid.org/0000-0002-4069-2481)
- Y Liu (ORCID: https://orcid.org/0009-0003-2050-9277)
- Zhe Ruan (ORCID: https://orcid.org/0000-0002-6714-6069)
- Chun‐Yuan Chen (ORCID: https://orcid.org/0000-0001-7808-533X)
- Yi Luo (ORCID: https://orcid.org/0000-0003-0007-0394)
- Zhenxing Wang (ORCID: https://orcid.org/0000-0001-7020-5202)
- Jia Cao (ORCID: https://orcid.org/0000-0002-9508-1397)
- Guo‐Qiang Zhu
- Jiang-Shan Gong
- Yi-Wei Liu (ORCID: https://orcid.org/0000-0003-1058-7717)
- Zhaohui Li (ORCID: https://orcid.org/0000-0002-4132-658X)
- Hui Xie (ORCID: https://orcid.org/0000-0002-8526-2637)
- Ling Jin (ORCID: https://orcid.org/0000-0003-3104-4439)
- Cheng Long
- Yiyi Wang (ORCID: https://orcid.org/0000-0002-4658-8394)
- Hao Luo (ORCID: https://orcid.org/0000-0002-2689-4343)
- Yin Hu (ORCID: https://orcid.org/0000-0002-5201-2471)
- Hao Yin (ORCID: https://orcid.org/0000-0002-8160-2139)
- Shushan Zhao (ORCID: https://orcid.org/0000-0001-9852-6219)
- Zhi-Rou Lin
Institutions
- Central South University (CN)
- Hunan University (CN)
- The First Hospital of Changsha (CN)
- Xiangya Hospital Central South University (CN)
- University of South China (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-03-30
- DOI
- https://doi.org/10.1186/s10020-025-01169-7
- Citations
- 4
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 4.61
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hainan Province
- Foundation for Innovative Research Groups of the National Natural Science Foundation of China
- National Outstanding Youth Science Fund Project of National Natural Science Foundation of China