Metformin ameliorates osteoporosis by enhancing bone angiogenesis via the YAP1/TAZ-HIF1α axis

Our findings suggest that metformin holds promise as a therapeutic agent for osteoporosis by enhancing type H vessel formation through the inhibition of the YAP1/TAZ-HIF1α axis.

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Publication Details

Journal
Molecular Medicine
Published
2025-03-30
DOI
https://doi.org/10.1186/s10020-025-01169-7
Citations
4
Primary Topic
Hippo pathway signaling and YAP/TAZ
Type
article
Field-Weighted Citation Impact
4.61

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article

Metformin ameliorates osteoporosis by enhancing bone angiogenesis via the YAP1/TAZ-HIF1α axis

Tengfei Wan, Jingtao Zou, Yong Zhu, Y Liu et al.
4 citations
Molecular Medicine
Hippo pathway signaling and YAP/TAZ
4.61
article

Metformin ameliorates osteoporosis by enhancing bone angiogenesis via the YAP1/TAZ-HIF1α axis

Tengfei Wan, Jingtao Zou, Yong Zhu, Y Liu, Zhe Ruan, Chun‐Yuan Chen, Yi Luo, Zhenxing Wang, Jia Cao, Guo‐Qiang Zhu, Jiang-Shan Gong, Yi-Wei Liu, Zhaohui Li, Hui Xie, Ling Jin, Cheng Long, Yiyi Wang, Hao Luo, Yin Hu, Hao Yin, Shushan Zhao, Zhi-Rou Lin
article en
4 citations

Abstract

Our findings suggest that metformin holds promise as a therapeutic agent for osteoporosis by enhancing type H vessel formation through the inhibition of the YAP1/TAZ-HIF1α axis.

Molecular MedicineVol. 31(1)
Central South University (CN), Hunan University (CN), The First Hospital of Changsha (CN), Xiangya Hospital Central South University (CN), University of South China (CN)
National Natural Science Foundation of China, Natural Science Foundation of Hainan Province, Foundation for Innovative Research Groups of the National Natural Science Foundation of China, National Outstanding Youth Science Fund Project of National Natural Science Foundation of China
Openalex Percentile: Top 6%
Hippo pathway signaling and YAP/TAZ
4.61
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