Zirconium Metal–Organic Frameworks as Micromotors with Enzyme-like Activity for Glutathione Detection
Herein, we report a novel UiO-67-Co(bpy)<sub>0.35</sub> micromotor synthesized by a facile postsynthesis metalation via introducing cobalt salts ligated with 2,2'-bipyridine-5,5'dicarboxylic acid into UiO-67-bpy<sub>0.35</sub> framework. The Co<sup>2+</sup> active sites can decompose H<sub>2</sub>O<sub>2</sub> to generate bubbles to power UiO-67-Co(bpy)<sub>0.35</sub>. Meanwhile, the UiO-67-Co(bpy)<sub>0.35</sub> micromotor exhibits robust peroxidase-like activity through catalyzing H<sub>2</sub>O<sub>2</sub> to generate <sup>•</sup>OH under neutral conditions. Based on this, a sensing platform was constructed for the colorimetric detection of GSH. Due to the synergy of self-driven motion and excellent peroxide-like activity, UiO-67-Co(bpy)<sub>0.35</sub> micromotor can sensitively detect GSH with a low analytic limitation as 0.13 μM for GSH detection. This study provides a new sight of using the postsynthesis metalation method to prepare Zr(Co)-MOF micromotor for highly selective, sensitive, and facile detection of GSH.
Authors
- Feng Jiang
- Ziwei Lan (ORCID: https://orcid.org/0000-0003-4495-1740)
- Dongyang Zhou
- Xiaoqing Li (ORCID: https://orcid.org/0000-0003-0816-8361)
- Jia Li (ORCID: https://orcid.org/0000-0003-2854-5208)
- Gui Wang
- Dickon H. L. Ng
Institutions
- University of Jinan (CN)
- Chinese University of Hong Kong, Shenzhen (CN)
Publication Details
- Journal
- Inorganic Chemistry
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1021/acs.inorgchem.5c00494
- Citations
- 5
- Primary Topic
- Metal-Organic Frameworks: Synthesis and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.69
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province