Phosphatase UBLCP1 is required for the growth, virulence and mitochondrial integrity of Toxoplasma gondii
UBLCP1 is required for the mitochondrial integrity and essential in the lytic cycle (e.g., host cell invasion and parasite replication) in vitro and the pathogenicity of this parasite in vivo. UBLCP1 is a candidate target for a vaccine or a drug for toxoplasmosis in animals.
Authors
- Kaiyue Song
- Guangxu Ma (ORCID: https://orcid.org/0000-0002-5929-7887)
- Aifang Du (ORCID: https://orcid.org/0000-0002-3796-6621)
- Yimin Yang (ORCID: https://orcid.org/0000-0003-2417-4550)
- Zhendong Du
- Kaiyin Sheng
- Xueqiu Chen
- Yi Yang (ORCID: https://orcid.org/0000-0003-0258-5308)
- Haiyan Wu
Institutions
- Zhejiang University (CN)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1186/s13071-025-06766-3
- Primary Topic
- Toxoplasma gondii Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China