Comparison of different lipid abnormalities between hemodialysis and peritoneal dialysis in patients with ESRD

Background: cardiovascular disease is the most common cause of death in patients with chronic kidney disease. Abnormalities of plasma lipids and lipoproteins are the underling cause in chronic kidney disease (CKD) patients. This study aimed to determine the prevalence of lipid disorders in end-stage renal disease (ESRD) patients undergoing hemodialysis (HD) and peritoneal dialysis and compare them between two groups. Methods: This cross-sectional study evaluated the lipid profile of 300 ESRD patients (150 HD and 150 PD) at baseline and one year after dialysis using the patients’ documents. Findings: One year after dialysis, serum total cholesterol, triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) levels were significantly higher in patients undergoing PD in comparison with HD groups (195.57±47.61 mg /dL vs. 157.89±44.04 mg /dL (P<0.001), 197.18±18.70 mg /dL vs 152.68±75.84 mg /dL (P<0.001), and 105.87±35.45 mg /dL vs 87.69±15.91 mg /dL (P=0.002). Serum high-density lipoprotein cholesterol (HDL-C) levels were lower in HD patients relative to PD (39.33±13.86 mg /dL vs. 51.92±20.11 mg /dL (P<0.001)). We observed a significantly higher frequency of serum TG>200 mg /dL and LDL-C>130 mg /dL in patients undergoing PD relative to HD. Serum HDL-C levels less than 40 mg /dL in men and less than 50 mg /dL in women were significantly more frequent in HD patients. Conclusion: The results of our study showed that dyslipidemia is more prevalent in ESRD patients undergoing PD which may cause cardiovascular events.