Role of TDP2 in the repair of DNA damage induced by the radiomimetic drug Bleomycin
The contribution of the TDP-related pathway to DSB repair significantly differed between IR and radiomimetic drugs. The discovery of this novel TDP2-dependent repair of DSBs resulting from radiomimetic drug exposure indicates that TDP1 and TDP2 inhibition in combination with radiomimetic drugs represents a strategy for cancer treatment.
Authors
- Ryosuke Morozumi
- Naoto Shimizu (ORCID: https://orcid.org/0000-0002-2046-9995)
- Mubasshir Washif (ORCID: https://orcid.org/0000-0002-0867-8460)
- Kazuki Izawa (ORCID: https://orcid.org/0000-0003-2509-5563)
- Kouji Hirota (ORCID: https://orcid.org/0000-0003-1676-979X)
- Masataka Tsuda (ORCID: https://orcid.org/0000-0002-1267-3777)
Institutions
- Hiroshima University (JP)
- National Institute of Health Sciences (JP)
- Tokyo Metropolitan University (JP)
Publication Details
- Journal
- Genes and Environment
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1186/s41021-025-00329-9
- Citations
- 1
- Primary Topic
- Cancer therapeutics and mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.81