Scalable and efficient electrochemical bromination of arenes with Faradaic efficiencies surpassing 90%
Developing cost-effective and environmentally friendly approaches to synthesize brominated chemicals, which are important intermediates for the synthesis of various useful molecules such as pharmaceuticals, surfactants, pesticides, and biologically active heterocyclic compounds, is of great significance. Herein, we present a highly efficient electrochemical bromine evolution reaction over vacancy rich Co<sub>3</sub>O<sub>4</sub> using cheap NaBr as the bromine source for the synthesis of valuable brominated fine chemicals and pharmaceuticals under ambient conditions. The introduction of oxygen vacancy onto Co<sub>3</sub>O<sub>4</sub> can greatly enhance the activity and selectivity of bromine evolution reaction by optimizing Br* intermediate adsorption and desorption, enabling bromination of a series of bioactive molecules and pharmaceuticals at high yields.
Authors
- Yuhou Pei (ORCID: https://orcid.org/0000-0002-9011-7194)
- Yu Lei (ORCID: https://orcid.org/0000-0003-4693-7408)
- Yinghua Xu (ORCID: https://orcid.org/0000-0001-9854-7845)
- Bing Zhang (ORCID: https://orcid.org/0000-0001-6114-1112)
- Zhu Liu (ORCID: https://orcid.org/0000-0003-3407-2072)
- Hong Bin Yang (ORCID: https://orcid.org/0000-0002-7834-4706)
- Chenliang Su (ORCID: https://orcid.org/0000-0002-8453-1938)
- Chuntian Qiu (ORCID: https://orcid.org/0000-0003-2315-4734)
- Bin Liu (ORCID: https://orcid.org/0000-0002-4685-2052)
- Wei Liu (ORCID: https://orcid.org/0000-0002-4403-737X)
- Di Li (ORCID: https://orcid.org/0000-0001-8052-926X)
- Jie Ding (ORCID: https://orcid.org/0000-0002-1427-9618)
- Yang Fan (ORCID: https://orcid.org/0009-0001-5135-1279)
Institutions
- City University of Hong Kong (HK)
- Zhejiang University of Science and Technology (CN)
- Shenzhen University (CN)
- Zhejiang University of Technology (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Nature Communications
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1038/s41467-025-57329-0
- Citations
- 9
- Primary Topic
- Vanadium and Halogenation Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- City University of Hong Kong
- National Natural Science Foundation of China
- Shenzhen University
- Department of Education of Guangdong Province
- National Postdoctoral Program for Innovative Talents
- National Key Research and Development Program of China