AO Spine Clinical Practice Recommendations: Current Systemic Oncological Treatments with the Largest Impact on Patients with Metastatic Spinal Disease

Study DesignLiterature review with clinical recommendation.ObjectiveTo provide the readers with a concise curation of the latest literature in recent advances in systemic oncological therapies and their implications for decision-making in patients with metastatic spinal disease. This review aims to enhance spine specialist's understanding of modern oncological treatments to facilitate optimal timing and planning of local interventions.MethodsThe latest literature in the topic of advances in oncology was reviewed by a multidisciplinary group of experts in metastatic spinal disease and clinical recommendations were formulated. The recommendations were dichotomously graded into strong and conditional (weak) based on the integration of scientific methodology and content expert opinion. This opinion considered experience and practical issues such as risks, burdens, costs, patient values, and circumstances.ResultsFour high-impact studies were reviewed, demonstrating significant advancements in systemic treatments for metastatic cancers commonly affecting the spine. These studies showed improved survival outcomes and efficacy across breast cancer, colorectal cancer, prostate cancer, and renal cell carcinoma. The findings have important implications for surgical/radiotherapy planning, including considerations for timing of interventions, wound healing, and the potential for extended survival affecting construct durability requirements.ConclusionsRecent advances in systemic oncological treatments have important implications for managing metastatic spinal disease. Understanding these developments is crucial for spine specialists to optimize decision-making through a multidisciplinary approach, particularly regarding timing of local interventions, strategy of the surgical approach and reconstruction.[Formula: see text].

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Publication Details

Journal
Global Spine Journal
Published
2025-03-28
DOI
https://doi.org/10.1177/21925682251324138
Citations
5
Primary Topic
Management of metastatic bone disease
Type
article
Field-Weighted Citation Impact
10.03
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article

AO Spine Clinical Practice Recommendations: Current Systemic Oncological Treatments with the Largest Impact on Patients with Metastatic Spinal Disease

SHREYASKUMAR R. PATEL, Kristin J. Redmond, Jiong Hao Tan, Arjun Sahgal et al.
5 citations
Global Spine Journal
Management of metastatic bone disease
10.03
article

AO Spine Clinical Practice Recommendations: Current Systemic Oncological Treatments with the Largest Impact on Patients with Metastatic Spinal Disease

SHREYASKUMAR R. PATEL, Kristin J. Redmond, Jiong Hao Tan, Arjun Sahgal, Jorrit‐Jan Verlaan, Joost Rutges, E. Wensink, Jeremy Reynolds, Áron Lazáry, Ilya Laufer, Laurence D. Rhines, Charles G. Fisher, Brian Guilherme Monteiro Marta Coimbra, Ori Barzilai, Alessandro Gasbarrini, Marcin Czyż, Michael Galgano, Cordula Netzer, Nicolas Dea
article en
5 citations

Abstract

Study DesignLiterature review with clinical recommendation.ObjectiveTo provide the readers with a concise curation of the latest literature in recent advances in systemic oncological therapies and their implications for decision-making in patients with metastatic spinal disease. This review aims to enhance spine specialist's understanding of modern oncological treatments to facilitate optimal timing and planning of local interventions.MethodsThe latest literature in the topic of advances in oncology was reviewed by a multidisciplinary group of experts in metastatic spinal disease and clinical recommendations were formulated. The recommendations were dichotomously graded into strong and conditional (weak) based on the integration of scientific methodology and content expert opinion. This opinion considered experience and practical issues such as risks, burdens, costs, patient values, and circumstances.ResultsFour high-impact studies were reviewed, demonstrating significant advancements in systemic treatments for metastatic cancers commonly affecting the spine. These studies showed improved survival outcomes and efficacy across breast cancer, colorectal cancer, prostate cancer, and renal cell carcinoma. The findings have important implications for surgical/radiotherapy planning, including considerations for timing of interventions, wound healing, and the potential for extended survival affecting construct durability requirements.ConclusionsRecent advances in systemic oncological treatments have important implications for managing metastatic spinal disease. Understanding these developments is crucial for spine specialists to optimize decision-making through a multidisciplinary approach, particularly regarding timing of local interventions, strategy of the surgical approach and reconstruction.[Formula: see text].

Global Spine JournalVol. 15(4)
University of North Carolina at Chapel Hill (US), Sunnybrook Health Science Centre (CA), Memorial Sloan Kettering Cancer Center (US), The University of Texas MD Anderson Cancer Center (US), University of British Columbia (CA), Johns Hopkins University (US), Johns Hopkins Medicine (US), Erasmus MC (NL), University Hospital of Basel (CH), University Medical Center Utrecht (NL), NYU Langone Health (US), Instituto do Câncer do Estado de São Paulo (BR), Kantonsspital Baselland (CH), National Center for Spinal Disorders (HU), Istituto Ortopedico Rizzoli (IT), NIHR Surgical Reconstruction and Microbiology Research Centre (GB), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR), National University Hospital (SG), Oxford University Hospitals NHS Trust (GB), Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Openalex Percentile: Top 2%
Management of metastatic bone disease
10.03
DOIOpen Access PDFOpenAlex
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