Relationship between Cumulative Exposure and Time Course of Plasma Aldosterone Concentrations and Chronic Kidney Disease in Hypertensive Patients: A Real-World Cohort Study
CKD risk is influenced by both annual PAC_AUC and the time course of PAC exposure. Participants exposed to elevated PAC earlier had a higher CKD risk than those exposed later, even at the same annual PAC_AUC. This highlights the importance of early PAC control to prevent CKD.
Authors
- Shuaiwei Song (ORCID: https://orcid.org/0009-0007-2444-2136)
- Xintian Cai (ORCID: https://orcid.org/0000-0003-3172-1540)
- Jing Hong
- Zhi‐Qiang Zhang (ORCID: https://orcid.org/0000-0003-4172-0592)
- Junli Hu (ORCID: https://orcid.org/0000-0003-1946-8714)
- Wen Jiang
- Delian Zhang
- Nanfang Li (ORCID: https://orcid.org/0000-0003-1505-8566)
- Wenbo Yang (ORCID: https://orcid.org/0000-0003-2156-0560)
- Yingying Zhang (ORCID: https://orcid.org/0009-0006-6505-6736)
- Qing Zhu (ORCID: https://orcid.org/0000-0003-0665-4753)
- Rui Ma (ORCID: https://orcid.org/0000-0002-9457-849X)
- Huimin Ma
- Pan Zhou (ORCID: https://orcid.org/0000-0001-9496-8810)
- Di Shen (ORCID: https://orcid.org/0009-0000-9819-5683)
Institutions
- Xinjiang Medical University (CN)
- People's Hospital of Xinjiang Uygur Autonomous Region (CN)
- Hypertension Institute (US)
Publication Details
- Journal
- American Journal of Nephrology
- Published
- 2025-03-29
- DOI
- https://doi.org/10.1159/000545451
- Citations
- 5
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 6.47