Low level of lactate and trophoblast dysfunction mediated by SNAI1/PDK1 contributes to miscarriage
Trophoblast spheroids may serve as reliable models to investigate the placenta. The regulatory mechanisms mediated by SNAI1/PDK1 in miscarriage have been elucidated. We provide new clues regarding the mechanism of miscarriage from a metabolic perspective and present evidence supporting lactate as a potential diagnostic marker.
Authors
- Fufen Yin
- Rui Gou (ORCID: https://orcid.org/0000-0002-6584-623X)
- Xiaohong Zhang (ORCID: https://orcid.org/0000-0003-4717-2777)
- Xiuju Yin
- Xue Zhong (ORCID: https://orcid.org/0000-0002-1958-1373)
- Tiantian Han (ORCID: https://orcid.org/0000-0002-4635-7174)
Institutions
- Peking University (CN)
- Peking University People's Hospital (CN)
Publication Details
- Journal
- Placenta
- Published
- 2025-03-29
- DOI
- https://doi.org/10.1016/j.placenta.2025.03.022
- Citations
- 1
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 2.06