Total Synthesis of Pegaharmine I Enabled by Visible‐Light Photocatalytic Nitrone Formation
The first total synthesis of pegaharmine I is accomplished by a three‐step strategy featuring a visible‐light‐photocatalyzed nitrone formation reaction as the key step. The structure of this natural product is confirmed by crystallographic analysis. Water‐promoted photocatalysis, achieved by incorporating water into the reaction medium, has also been established.
Authors
- Bor‐Cherng Hong (ORCID: https://orcid.org/0000-0002-4623-3366)
- Su‐Ying Chien (ORCID: https://orcid.org/0009-0008-0931-3149)
- H.-F. Lu
- Manikanta Swami Pothana
Institutions
- National Chung Cheng University (TW)
- National Taiwan University (TW)
- National Taipei University (TW)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2025-03-29
- DOI
- https://doi.org/10.1002/ejoc.202500245
- Primary Topic
- Synthesis of Indole Derivatives
- Type
- article
- Field-Weighted Citation Impact
- 0.00