NAT10 promotes gastric cancer progression by enhancing the N4-acetylcytidine modification of TNC mRNA
In summary, our results reveal that NAT10 plays a critical role in GC development by affecting TNC mRNA stability and translation efficiency, which ultimately activates the TNC/Akt/TGF-β1 positive feedback loop. This study is expected to provide a novel target and theoretical basis for improving the diagnosis and treatment of GC.
Authors
- Zhiwei Qin (ORCID: https://orcid.org/0000-0003-4304-4524)
- Bin Lan (ORCID: https://orcid.org/0000-0002-2951-8087)
- Jiuhua Xu (ORCID: https://orcid.org/0000-0003-3737-6696)
- Ruilong Kou
- Yu Chen (ORCID: https://orcid.org/0000-0003-1348-8992)
- Jinzhou Wang (ORCID: https://orcid.org/0000-0002-6767-6967)
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Infectious Agents and Cancer
- Published
- 2025-03-29
- DOI
- https://doi.org/10.1186/s13027-025-00650-6
- Citations
- 5
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- Science and Technology Projects of Fujian Province
- Natural Science Foundation of Fujian Province