Manipulating subcellular protein localization to enhance target protein accumulation in minicells
These findings highlight the critical role of spatial protein organization in enhancing the cargo-loading capabilities of minicells. By leveraging polar localization signals, this work provides a robust framework for optimizing minicells as efficient carriers for diverse applications, from therapeutic delivery to industrial biomanufacturing.
Authors
- Junhyeon Park (ORCID: https://orcid.org/0000-0003-1069-1813)
- Karen M. Polizzi (ORCID: https://orcid.org/0000-0001-5435-2667)
- Jongmin Kim (ORCID: https://orcid.org/0000-0002-2713-1006)
- Juhyun Kim (ORCID: https://orcid.org/0000-0002-8449-4591)
Institutions
- Pohang University of Science and Technology (KR)
- Kyungpook National University (KR)
- Imperial College London (GB)
Publication Details
- Journal
- Journal of Biological Engineering
- Published
- 2025-03-29
- DOI
- https://doi.org/10.1186/s13036-025-00495-y
- Citations
- 5
- Primary Topic
- Bacterial Genetics and Biotechnology
- Type
- article
- Field-Weighted Citation Impact
- 9.09
Funders
- Ministry of Science and ICT, South Korea