Palladium nanoparticles for aerobic oxidative Heck arylation of alkenes

Abstract Herein, we report a palladium nanoparticle-catalyzed aerobic oxidative Heck arylation of alkenes with aryl boronic acids, yielding a range of (E)-β-aryl acrylates and (E)-stilbene derivatives. This reaction uses molecular oxygen as the terminal oxidant, requiring no base or additional oxidants. The catalyst displays notable tolerance to unprotected amide groups, surpassing conventional strategies.