Natural Products in Aging: Cellular Mechanisms and Emerging Therapeutics for Age‐Related Disorders

Aging is a natural biological process characterized by the gradual decline of physiological functions, leading to an increased risk of chronic diseases and heightened susceptibility to mortality. This review investigates the therapeutic potential of natural products in modifying aging‐related cellular processes, including OS, inflammation, and senescence. Since ancient times, herbal treatments have been utilized extensively throughout civilizations. Their ability to treat age‐related illnesses has been well documented, and they have significantly impacted research on aging. We investigate the cellular mechanisms of action of substances such as rapamycin, resveratrol, and its derivatives, including their functions in controlling important signaling pathways and reducing oxidative damage. This review thoroughly explains the underlying mechanisms of aging‐related illnesses and how natural chemicals may be used as valuable scaffolds for developing new drugs. The current manuscript highlights the potential of natural ingredients as treatments for aging management and better therapeutic results in the future.

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Publication Details

Journal
Journal of Aging Research
Published
2025-01-01
DOI
https://doi.org/10.1155/jare/6868732
Citations
3
Primary Topic
Medicinal Plants and Bioactive Compounds
Type
article
Field-Weighted Citation Impact
2.42
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article

Natural Products in Aging: Cellular Mechanisms and Emerging Therapeutics for Age‐Related Disorders

Rakesh Kumar Bachheti, Limenew Abate Worku, Deen Dayal, Archana Bachheti et al.
3 citations
Journal of Aging Research
Medicinal Plants and Bioactive Compounds
2.42
article

Natural Products in Aging: Cellular Mechanisms and Emerging Therapeutics for Age‐Related Disorders

Rakesh Kumar Bachheti, Limenew Abate Worku, Deen Dayal, Archana Bachheti, B. T. Manjunath, Kundan Kumar Chaubey, Pranjali Bajrang Chole, Prakash C. Gupta, Versha Dixit
article en
3 citations

Abstract

Aging is a natural biological process characterized by the gradual decline of physiological functions, leading to an increased risk of chronic diseases and heightened susceptibility to mortality. This review investigates the therapeutic potential of natural products in modifying aging‐related cellular processes, including OS, inflammation, and senescence. Since ancient times, herbal treatments have been utilized extensively throughout civilizations. Their ability to treat age‐related illnesses has been well documented, and they have significantly impacted research on aging. We investigate the cellular mechanisms of action of substances such as rapamycin, resveratrol, and its derivatives, including their functions in controlling important signaling pathways and reducing oxidative damage. This review thoroughly explains the underlying mechanisms of aging‐related illnesses and how natural chemicals may be used as valuable scaffolds for developing new drugs. The current manuscript highlights the potential of natural ingredients as treatments for aging management and better therapeutic results in the future.

Journal of Aging ResearchVol. 2025(1)
Chandigarh University (IN), Chhatrapati Shahu Ji Maharaj University (IN), The Sanskrit College and University (IN), Uttaranchal University (IN), Debre Tabor University (ET), Christ University (IN), Graphic Era University (IN), GLA University (IN), Saveetha University (IN)
Openalex Percentile: Top 12%
Medicinal Plants and Bioactive Compounds
2.42
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