Multimodal precision MRI of the individual human brain at ultra-high fields
Multimodal neuroimaging, in particular magnetic resonance imaging (MRI), allows for non-invasive examination of human brain structure and function across multiple scales. Precision neuroimaging builds upon this foundation, enabling the mapping of brain structure, function, and connectivity patterns with high fidelity in single individuals. Highfield MRI, operating at magnetic field strengths of 7 Tesla (T) or higher, increases signal-to-noise ratio and opens up possibilities for gains spatial resolution. Here, we share a multimodal Precision Neuroimaging and Connectomics (PNI) 7 T MRI dataset. Ten healthy individuals underwent a comprehensive MRI protocol, including T1 relaxometry, magnetization transfer imaging, T2*-weighted imaging, diffusion MRI, and multi-state functional MRI paradigms, aggregated across three imaging sessions. Alongside anonymized raw MRI data, we release cortex-wide connectomes from different modalities across multiple parcellation scales, and supply "gradients" that compactly characterize spatial patterning of cortical organization. Our precision MRI dataset will advance our understanding of structure-function relationships in the individual human brain and is publicly available via the Open Science Framework.
Authors
- Boris C. Bernhardt (ORCID: https://orcid.org/0000-0001-9256-6041)
- Nicole Eichert (ORCID: https://orcid.org/0000-0001-7818-5787)
- Oualid Benkarim (ORCID: https://orcid.org/0000-0003-3922-7643)
- Casey Paquola (ORCID: https://orcid.org/0000-0002-0190-4103)
- Raúl Rodríguez‐Cruces (ORCID: https://orcid.org/0000-0002-2917-1212)
- Jessica Royer (ORCID: https://orcid.org/0000-0002-4448-8998)
- Christine Tardif (ORCID: https://orcid.org/0000-0001-8356-6808)
- Jordan DeKraker (ORCID: https://orcid.org/0000-0002-4093-0582)
- Donna Gift Cabalo (ORCID: https://orcid.org/0000-0001-9568-1723)
- Shahin Tavakol (ORCID: https://orcid.org/0000-0002-7585-8963)
- Julien Doyon (ORCID: https://orcid.org/0000-0002-3788-4271)
- Youngeun Hwang (ORCID: https://orcid.org/0000-0002-6921-0423)
- Yezhou Wang (ORCID: https://orcid.org/0000-0003-3650-5476)
- Risavarshni Thevakumaran (ORCID: https://orcid.org/0000-0003-4366-8695)
- Valeria Kebets (ORCID: https://orcid.org/0000-0003-1707-7437)
- David A. Rudko (ORCID: https://orcid.org/0000-0002-1299-954X)
- Jonathan Smallwood (ORCID: https://orcid.org/0000-0002-7298-2459)
- Ilana R. Leppert (ORCID: https://orcid.org/0000-0001-7672-0918)
- Yigu Zhou
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Forschungszentrum Jülich (DE)
- Queen's University (CA)
- University of Oxford (GB)
- McGill University (CA)
Publication Details
- Journal
- Scientific Data
- Published
- 2025-03-29
- DOI
- https://doi.org/10.1038/s41597-025-04863-7
- Citations
- 15
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 20.40