Comprehensive Review of Conservative and Surgical Treatment Strategies for Knee Osteoarthritis: Efficacy, Safety, and Emerging Therapies
Knee osteoarthritis (KOA) is a chronic degenerative joint disorder that significantly impairs mobility and quality of life. While surgical interventions such as total knee arthroplasty (TKA) are effective in severe cases, conservative treatments are critical for early and intermediate disease management. This review evaluates the efficacy, safety, and clinical applications of both conservative and surgical treatment approaches, including lifestyle modifications, physical therapy, pharmacological interventions, regenerative medicine, and surgical procedures. The integration of a multidisciplinary approach is emphasized as a key strategy for optimizing clinical outcomes and tailoring interventions to disease severity.
Authors
- Fernanda Grazielle da Silva Azevedo Nora (ORCID: https://orcid.org/0000-0002-0880-1326)
- Gabriel Rodrigues Martins de Freitas (ORCID: https://orcid.org/0000-0001-9938-3977)
- L Silva (ORCID: https://orcid.org/0000-0003-4096-5563)
- Helder Rocha da Silva Araújo (ORCID: https://orcid.org/0000-0003-1411-2233)
- Sara Pinto Barbosa (ORCID: https://orcid.org/0000-0002-9802-9674)
- Andrei Machado Viegas da Trindade (ORCID: https://orcid.org/0000-0002-6550-4037)
- Isabella Luiza das graças Rocha Borges
- Maria Tereza Guay de Goiás
- Thamara Cardoso Jacob
- Fabiano Bottino Cançado
Institutions
- Hospital de Base (BR)
- Universidade Estadual de Goiás (BR)
- Hospital de Base (BR)
- Universidade Federal de Goiás (BR)
Publication Details
- Journal
- Trends journal of sciences research
- Published
- 2025-03-29
- DOI
- https://doi.org/10.31586/gjo.2025.6016
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00