Association between single nucleotide polymorphisms of DNA repair genes (BRCA1, BRCA2, and PALB2) and breast cancer incidence in a subset of Iranian population
Our findings suggest no significant association between the rs386833395 polymorphism and BC risk in the Iranian Kurdish population, while rs80359550 and rs180177102 polymorphisms were strongly associated with BC. However, the study has several limitations, including its retrospective design, a relatively small sample size, and the potential lack of generalizability to other ethnic groups within Iran. Future studies involving larger cohorts and more diverse populations are needed to confirm these results.
Authors
- Zahra Abdan (ORCID: https://orcid.org/0000-0003-3209-5262)
- Mozaffar Aznab (ORCID: https://orcid.org/0000-0002-1498-5205)
- Massoud Houshmand (ORCID: https://orcid.org/0000-0002-2198-223X)
- Sepideh Jahangiri
- Ali Souroush
Institutions
- Kermanshah University of Medical Sciences (IR)
- Imam Reza Hospital (IR)
- National Institute of Genetic Engineering and Biotechnology (IR)
Publication Details
- Journal
- Hereditary Cancer in Clinical Practice
- Published
- 2025-03-29
- DOI
- https://doi.org/10.1186/s13053-025-00311-0
- Citations
- 1
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Kermanshah University of Medical Sciences