The effects of sodium-glucose transporter 2 inhibition on cardiac surgery-associated acute kidney injury: An open-label randomized pilot study
In this pilot study, perioperative SGLT2 inhibition was not associated with lower NGAL levels. We observed that SGLT2 inhibition reduced the incidence of acute kidney injury in this small study population. As the results of this pilot study are hypotheses-generating, further validation is needed in a large-scale, double-blind, placebo-controlled, randomized trial, which is currently ongoing.
Authors
- Benedikt Preckel (ORCID: https://orcid.org/0000-0003-4412-9183)
- Elena Rampanelli (ORCID: https://orcid.org/0000-0002-7742-0092)
- Yugeesh R. Lankadeva (ORCID: https://orcid.org/0000-0002-3589-9111)
- Jeroen Hermanides (ORCID: https://orcid.org/0000-0003-2239-1260)
- Abraham H. Hulst (ORCID: https://orcid.org/0000-0001-9101-7649)
- Daniël H. van Raalte (ORCID: https://orcid.org/0000-0003-2894-6124)
- Mark Philip Plummer (ORCID: https://orcid.org/0000-0002-9640-1911)
- Maartina J P Oosterom-Eijmael (ORCID: https://orcid.org/0000-0002-2906-2518)
- Lars I.P. Snel
Institutions
- Royal Adelaide Hospital (AU)
- The Royal Melbourne Hospital (AU)
- The University of Melbourne (AU)
- Florey Institute of Neuroscience and Mental Health (AU)
- Amsterdam Neuroscience (NL)
- Amsterdam Institute for Addiction Research (NL)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Journal of Clinical Anesthesia
- Published
- 2025-03-29
- DOI
- https://doi.org/10.1016/j.jclinane.2025.111811
- Citations
- 21
- Primary Topic
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Type
- article
- Field-Weighted Citation Impact
- 27.19
Funders
- European Commission
- H2020 Marie Skłodowska-Curie Actions