Lactiplantibacillus plantarum FRT4 protects against fatty liver hemorrhage syndrome: regulating gut microbiota and FoxO/TLR-4/NF-κB signaling pathway in laying hens
Lp. plantarum FRT4 effectively ameliorates FLHS in laying hens. This efficacy is attributed to its antioxidant and anti-inflammatory properties, which are mediated by modulating the structure and function of gut microbiota, and further intervening in the FoxO/TLR-4/NF-κB signaling pathway. These actions enhance hepatic and ovarian function and increase estrogen levels. Video Abstract.
Authors
- Xin Xu (ORCID: https://orcid.org/0000-0003-3395-9923)
- Daojie Li
- Liye Song (ORCID: https://orcid.org/0009-0009-0499-8027)
- Kun Meng (ORCID: https://orcid.org/0000-0002-6541-9510)
- Peilong Yang (ORCID: https://orcid.org/0000-0002-9037-2769)
- Weiwei Liu (ORCID: https://orcid.org/0000-0002-9035-0359)
- Guohua Liu (ORCID: https://orcid.org/0000-0002-9120-0977)
- Yunsheng Han
- Hongying Cai (ORCID: https://orcid.org/0000-0002-5688-6969)
- Zhiguo Wen (ORCID: https://orcid.org/0000-0003-3477-2298)
Institutions
- Chinese Academy of Agricultural Sciences (CN)
- Feed Research Institute (CN)
- Ministry of Agriculture and Rural Affairs (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2025-03-29
- DOI
- https://doi.org/10.1186/s40168-025-02083-0
- Citations
- 13
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 17.60