SUSTAINED FAVORABLE IMPACT OF MAVACAMTEN ON BIOMARKERS FOR CARDIOPULMONARY STRESS AND HEMOLYSIS IN PATIENTS WITH OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY FROM THE MAVA-LTE (EXPLORER COHORT) AND VALOR-HCM STUDIES
Mavacamten improved cardiac functionand symptoms in patients with obstructive Hypertrophic Cardiomyopathy (HCM) in MAVA-LTE and VALOR-HCM, while favorable circulating proteomic profile changes were observed following mavacamnten treatment in EXPLORER-HCM.
Authors
- Kathy Lampl
- Ganesh Balaratnam
- Milind Y. Desai (ORCID: https://orcid.org/0000-0003-0010-9797)
- Myeong‐Jin Kim (ORCID: https://orcid.org/0000-0001-7949-5402)
- Aiqing He
- Warren D. Anderson (ORCID: https://orcid.org/0000-0002-7235-5869)
- Iacopo Olivotto
- Chen Yao (ORCID: https://orcid.org/0000-0003-0327-9599)
- Zhaoqing Wang (ORCID: https://orcid.org/0000-0003-1515-4945)
- Peter Schäfer (ORCID: https://orcid.org/0000-0002-3880-0850)
Institutions
- Bristol-Myers Squibb (United States) (US)
Publication Details
- Journal
- Journal of the American College of Cardiology
- Published
- 2025-03-29
- DOI
- https://doi.org/10.1016/s0735-1097(25)01736-x
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00