Deubiquitinase OTUD7B stabilizes HNF4α to alleviate pressure overload-induced cardiac hypertrophy by regulating fatty acid oxidation and inhibiting ferroptosis
We confirmed that OTUD7B is involved in the regulation of ferroptosis in pressure overload-induced cardiac hypertrophy and highlighted that OTUD7B alleviates cardiac hypertrophy by regulating ferroptosis and fatty acid oxidation through deubiquitination and stabilization of HNF4α.
Authors
- Wenjuan Song (ORCID: https://orcid.org/0000-0003-1560-757X)
- Xiaotong Sun (ORCID: https://orcid.org/0000-0001-5628-0994)
- R Q Zheng (ORCID: https://orcid.org/0000-0001-7959-1226)
- Che Wang (ORCID: https://orcid.org/0000-0001-5775-2236)
- Chengzhi Lu (ORCID: https://orcid.org/0000-0002-4546-6395)
- Chunlei Liu (ORCID: https://orcid.org/0000-0002-0260-8074)
- Xiaoyu Du
Institutions
- Nankai University (CN)
- Tianjin First Center Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Biomarker Research
- Published
- 2025-03-29
- DOI
- https://doi.org/10.1186/s40364-025-00766-2
- Citations
- 2
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Tianjin City