Dual-channel pulse-dye densitometry can enable correction of fluorescent targeted and control agent plasma input function differences for quantitative paired-agent molecular imaging: a simulation study
These results highlight the potential for developing a PDD instrument that can directly measure targeted and control agent PIFs and be used to correct for any PIF differences between agents for more quantitative estimates of BP in paired-agent imaging studies.
Authors
- Cody C. Rounds (ORCID: https://orcid.org/0009-0003-2586-2731)
- Jovan G. Brankov (ORCID: https://orcid.org/0000-0001-6398-4711)
- Kimberly S. Samkoe
- Kenneth M. Tichauer (ORCID: https://orcid.org/0000-0003-1667-3026)
- Yichen Feng
- Sanjana Pannem (ORCID: https://orcid.org/0009-0005-0690-4224)
Institutions
- Dartmouth College (US)
- Illinois Institute of Technology (US)
Publication Details
- Journal
- Journal of Biomedical Optics
- Published
- 2025-03-29
- DOI
- https://doi.org/10.1117/1.jbo.30.4.046001
- Primary Topic
- Mass Spectrometry Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health