EXPLORING LULICONAZOLE AS A POTENT ANTIFUNGAL AGENT: MOLECULAR DOCKING FOR INTERACTION STUDIES IN THE DEVELOPMENT OF FORMULATION

Continuous efforts are being made in pharmaceutical research to enhance the effectiveness of existing medications through the research and development of new drug delivery systems (DDS).Recent advancements in high-throughput screening have led to the development of lipophilic Active Pharmaceutical Ingredients (APIs).An example of a topical broad-spectrum antifungal agent is Luliconazole.Because of its poor water solubility, topical administration is limited, and topical absorption is restricted.The solubility of the drug in the stratum corneum's lipid phase also acts as a rate-limiting stage in penetration.Fungal infections impact the epidermis, dermis, and deeper layers of skin, necessitating treatment delivery tailored to target high drug concentrations at the epidermis and dermis layers.The present study involves interaction between the ideal candidates to optimize the Nano emulation.Interaction based on Docking provides Ricinoleic acid, a measured component of Caster oil, in addition to tween 80 and ethanol.The present study involves molecular docking studies that revealed an interesting binding profile.