Culturomics of the pig tonsil microbiome identifies new species and an untapped source of novel antimicrobials
We defined the core tonsil microbiota of piglets and cultured representative single bacterial isolates for research on microbiota-host interactions in the oral cavity. Several isolates inhibiting the growth of bacterial pathogens that might be exploited as probiotics to promote colonization resistance were deposited in publicly available strain repositories. Our mining of genomes from cultured isolates suggests that the tonsil microbiota is an untapped source of novel antimicrobials Video Abstract.
Authors
- Hermie J. M. Harmsen (ORCID: https://orcid.org/0000-0003-2725-6148)
- Isabela Maria Fernandes de Oliveira (ORCID: https://orcid.org/0000-0002-5004-0241)
- Simen Fredriksen (ORCID: https://orcid.org/0000-0002-7872-7969)
- Marcela Fernández Gutiérrez
- Peter van Baarlen (ORCID: https://orcid.org/0000-0003-3530-5472)
- Jerry Mark Wells (ORCID: https://orcid.org/0000-0002-8743-2652)
- Jos Boekhorst (ORCID: https://orcid.org/0000-0002-4807-7838)
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- University of Cambridge (GB)
- Wageningen University & Research (NL)
Publication Details
- Journal
- Microbiome
- Published
- 2025-03-29
- DOI
- https://doi.org/10.1186/s40168-025-02064-3
- Citations
- 3
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- European Commission