MiR-103-3p regulates chondrocyte autophagy, apoptosis, and ECM degradation through the PI3K/Akt/mTOR pathway by targeting CPEB3
Overall, inhibition of miR-103-3p reduces IL-1β-induced apoptosis and ECM macromolecule degradation in chondrocytes by enhancing autophagy through the CPEB3/PI3K/Akt/mTOR pathway.
Authors
- Xi'an Pan
- Farui Sun
- Qian Zhou (ORCID: https://orcid.org/0000-0002-6289-1668)
- Jun Li (ORCID: https://orcid.org/0000-0003-4525-8278)
- Bo Li (ORCID: https://orcid.org/0000-0003-0022-0583)
- Guofu Zhang (ORCID: https://orcid.org/0000-0001-9105-0385)
- Yuanjin Zhang
Institutions
- Hubei Polytechnic University (CN)
- Huangshi Central Hospital (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-03-29
- DOI
- https://doi.org/10.1186/s13018-025-05719-x
- Citations
- 6
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 10.01