The dual role of titanium particles in osteolysis: implications for gene therapy in prosthesis loosening
These results highlight the dual role of titanium particles in periprosthetic osteolysis and underscore the potential of a gene therapy strategy targeting both inflammatory factors and the Wnt signaling pathway to improve knee prosthesis loosening. This study provides a scientific foundation for developing novel therapeutic approaches.
Authors
- Ping Chen (ORCID: https://orcid.org/0000-0002-8504-5552)
- Qunhua Jin (ORCID: https://orcid.org/0000-0001-7616-3357)
- Ke Sun (ORCID: https://orcid.org/0000-0003-4520-6953)
- Long Wu (ORCID: https://orcid.org/0000-0003-0212-6419)
- Shuai Zhang (ORCID: https://orcid.org/0000-0003-3015-242X)
- Haohui Guo
Institutions
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-03-29
- DOI
- https://doi.org/10.1186/s40001-025-02452-3
- Citations
- 1
- Primary Topic
- Orthopaedic implants and arthroplasty
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Ningxia Medical University