Metabolic Insights into Urinary Stone Formation: Evidence from Mendelian Randomization, Clinical, and in vivo Studies
Our study establishes causal links between specific metabolites and urinary stones, shedding light on the intricate biological mechanisms of stone formation. The discovery of mannose as a protective factor opens avenues for future research and clinical applications, offering promising directions for the prevention and treatment of stones.
Authors
- Qi‐Dong Xia (ORCID: https://orcid.org/0000-0002-2278-1122)
- Jian‐Xuan Sun (ORCID: https://orcid.org/0000-0003-2667-1200)
- Senyuan Hong (ORCID: https://orcid.org/0000-0002-0466-0917)
- Lin-Tao Miao (ORCID: https://orcid.org/0000-0001-8087-8048)
- Sihan Zhang (ORCID: https://orcid.org/0009-0009-4700-8943)
- Jiacheng Xiang
- Yuan Gong (ORCID: https://orcid.org/0000-0002-2031-0968)
- Shaogang Wang (ORCID: https://orcid.org/0000-0002-3206-1495)
- Yuanyuan Yang
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Kidney Diseases
- Published
- 2025-03-29
- DOI
- https://doi.org/10.1159/000545550
- Citations
- 1
- Primary Topic
- Kidney Stones and Urolithiasis Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.52