3D culturing as a promising strategy to enhance the angiogenic potential of adipose stem cell-derived secretome: insights into the role of miR-145-5p/ANGPT2 axis
All these findings corroborate our hypothesis that 3D culturing is able to positively modulate ASC gene expression and secretome composition in terms of pro-angiogenic potential. Indeed, our study contributes to shed light on the role of the miR-145-5p/ANGPT2 axis in this process, opening the way to innovative potentiation strategies to implement secretome-based therapies, with broad clinical applications.
Authors
- Danilo Ranieri (ORCID: https://orcid.org/0000-0001-5039-0834)
- Giulia Gerini (ORCID: https://orcid.org/0000-0002-9229-5103)
- Emanuela Mari (ORCID: https://orcid.org/0000-0003-2367-3139)
- Simona Camero (ORCID: https://orcid.org/0000-0001-8286-3640)
- Francesca Megiorni (ORCID: https://orcid.org/0000-0003-3705-3248)
- Antonio Angeloni (ORCID: https://orcid.org/0000-0003-4969-9548)
- Simona Ceccarelli (ORCID: https://orcid.org/0000-0001-8789-7719)
- Paola Pontecorvi (ORCID: https://orcid.org/0000-0003-2392-3775)
- Cinzia Marchese (ORCID: https://orcid.org/0000-0002-9280-8917)
- Enrico Romano (ORCID: https://orcid.org/0000-0001-9514-6472)
- Paolo Fioramonti
Institutions
- Policlinico Umberto I (IT)
- Link Campus University (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1186/s13287-025-04277-7
- Citations
- 1
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Sapienza Università di Roma