Extended Reduced-Dose Apixaban for Cancer-Associated Venous Thromboembolism

Extended anticoagulation with reduced-dose apixaban was noninferior to full-dose apixaban for the prevention of recurrent venous thromboembolism in patients with active cancer. The reduced dose led to a lower incidence of clinically relevant bleeding complications than the full dose. (Funded by the Bristol-Myers Squibb-Pfizer Alliance; API-CAT ClinicalTrials.gov number, NCT03692065.).

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Publication Details

Journal
New England Journal of Medicine
Published
2025-03-29
DOI
https://doi.org/10.1056/nejmoa2416112
Citations
95
Primary Topic
Venous Thromboembolism Diagnosis and Management
Type
article
Field-Weighted Citation Impact
177.63

Funders

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article

Extended Reduced-Dose Apixaban for Cancer-Associated Venous Thromboembolism

Olivier Sanchez, Juan J. López-Núñez, Remedios Otero, Philippe Girard et al.
95 citations
New England Journal of Medicine
Venous Thromboembolism Diagnosis and Management
177.63
article

Extended Reduced-Dose Apixaban for Cancer-Associated Venous Thromboembolism

Olivier Sanchez, Juan J. López-Núñez, Remedios Otero, Philippe Girard, Adam Torbicki, Sebastian Szmit, Laurent Bertoletti, Peter E. Westerweel, Silvy Laporte, Isabelle Mahé, Menno V. Huisman, Cihan Ay, Marc Righini, Aristotelis Bamias, Patrick Mismetti, Grégoire Le Gal, Nicolas Falvo, Marc Carrier, D. Mayeur, Frederikus Albertus Klok, Peter Verhamme, Jean Chidiac, Anthony Maraveyas, Cecilia Becattini, Céline Chapelle, Françis Couturaud, Erik Yeo, Éric Vicaut, C. Grangé, Helia Robert-Ebadi, Guy Meyer, Giancarlo Agnelli, Kostas Syrigos, Alexander T. Cohen, Manuel Monreal
article en
95 citations

Abstract

Extended anticoagulation with reduced-dose apixaban was noninferior to full-dose apixaban for the prevention of recurrent venous thromboembolism in patients with active cancer. The reduced dose led to a lower incidence of clinically relevant bleeding complications than the full dose. (Funded by the Bristol-Myers Squibb-Pfizer Alliance; API-CAT ClinicalTrials.gov number, NCT03692065.).

New England Journal of MedicineVol. 392(14)
Universitat Autònoma de Barcelona (ES), University Health Network (CA), University of Ottawa (CA), Inserm (FR), Université de Bretagne Occidentale (FR), King's College London (GB), Guy's and St Thomas' NHS Foundation Trust (GB), National and Kapodistrian University of Athens (GR), Université Paris Cité (FR), University of Perugia (IT), Leiden University Medical Center (NL), Ottawa Hospital (CA), Toronto General Hospital (CA), Mines Saint-Étienne (FR), Hôpital Louis-Mourier (FR), Albert Schweitzer Ziekenhuis (NL), Institute Mutualiste Montsouris (FR), Comprehensive Cancer Center Vienna (AT), Centre Georges François Leclerc (FR), Assistance Publique – Hôpitaux de Paris (FR), Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (ES), Hospices Civils de Lyon (FR), Hôpital Européen Georges-Pompidou (FR), Hôpital Européen (FR), Institute Cancer De La Loire Lucien Neuwirth (FR), CHU Dijon Bourgogne (FR), Hôpital Lariboisière (FR), Paris Cardiovascular Research Center (FR), Centre Hospitalier Régional Universitaire de Brest (FR), Postgraduate School of Molecular Medicine (PL), Association Francophone pour les Soins Oncologiques de Support (FR), UniCancer Group (FR), Hospital Universitario Virgen del Rocío (ES), Hospital Universitari Germans Trias i Pujol (ES), Centre Hospitalier Universitaire de Saint-Étienne (FR), Sotiria General Hospital (GR), French Clinical Research Infrastructure Network (FR), Geneva College (US), Universidad Católica de Murcia (ES), Hull York Medical School (GB), Medical University of Vienna (AT), Universidad de Sevilla (ES), Université Jean Monnet (FR), KU Leuven (BE)
Bristol-Myers Squibb
Good health and well-being
Openalex Percentile: Top 0%
Venous Thromboembolism Diagnosis and Management
177.63
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