Extended Reduced-Dose Apixaban for Cancer-Associated Venous Thromboembolism
Extended anticoagulation with reduced-dose apixaban was noninferior to full-dose apixaban for the prevention of recurrent venous thromboembolism in patients with active cancer. The reduced dose led to a lower incidence of clinically relevant bleeding complications than the full dose. (Funded by the Bristol-Myers Squibb-Pfizer Alliance; API-CAT ClinicalTrials.gov number, NCT03692065.).
Authors
- Olivier Sanchez (ORCID: https://orcid.org/0000-0003-1633-8391)
- Juan J. López-Núñez
- Remedios Otero (ORCID: https://orcid.org/0000-0002-2265-1221)
- Philippe Girard (ORCID: https://orcid.org/0000-0002-1559-8055)
- Adam Torbicki (ORCID: https://orcid.org/0000-0003-3475-8832)
- Sebastian Szmit (ORCID: https://orcid.org/0000-0002-3075-1943)
- Laurent Bertoletti (ORCID: https://orcid.org/0000-0001-8214-3010)
- Peter E. Westerweel (ORCID: https://orcid.org/0000-0002-0746-7039)
- Silvy Laporte (ORCID: https://orcid.org/0000-0001-6197-8668)
- Isabelle Mahé (ORCID: https://orcid.org/0000-0003-1760-7880)
- Menno V. Huisman (ORCID: https://orcid.org/0000-0003-1423-5348)
- Cihan Ay (ORCID: https://orcid.org/0000-0003-2607-9717)
- Marc Righini (ORCID: https://orcid.org/0000-0003-1211-2969)
- Aristotelis Bamias (ORCID: https://orcid.org/0000-0002-5996-7262)
- Patrick Mismetti (ORCID: https://orcid.org/0000-0003-1511-0555)
- Grégoire Le Gal (ORCID: https://orcid.org/0000-0002-9253-248X)
- Nicolas Falvo
- Marc Carrier (ORCID: https://orcid.org/0000-0001-8296-2972)
- D. Mayeur (ORCID: https://orcid.org/0000-0003-4724-7871)
- Frederikus Albertus Klok (ORCID: https://orcid.org/0000-0001-9961-0754)
- Peter Verhamme (ORCID: https://orcid.org/0000-0001-8698-2858)
- Jean Chidiac
- Anthony Maraveyas (ORCID: https://orcid.org/0000-0003-4176-5176)
- Cecilia Becattini
- Céline Chapelle (ORCID: https://orcid.org/0000-0003-3281-3666)
- Françis Couturaud (ORCID: https://orcid.org/0000-0002-1855-8032)
- Erik Yeo (ORCID: https://orcid.org/0000-0003-2298-3848)
- Éric Vicaut (ORCID: https://orcid.org/0000-0001-6303-8557)
- C. Grangé
- Helia Robert-Ebadi
- Guy Meyer
- Giancarlo Agnelli
- Kostas Syrigos
- Alexander T. Cohen
- Manuel Monreal
Institutions
- Universitat Autònoma de Barcelona (ES)
- University Health Network (CA)
- University of Ottawa (CA)
- Inserm (FR)
- Université de Bretagne Occidentale (FR)
- King's College London (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- National and Kapodistrian University of Athens (GR)
- Université Paris Cité (FR)
- University of Perugia (IT)
- Leiden University Medical Center (NL)
- Ottawa Hospital (CA)
- Toronto General Hospital (CA)
- Mines Saint-Étienne (FR)
- Hôpital Louis-Mourier (FR)
- Albert Schweitzer Ziekenhuis (NL)
- Institute Mutualiste Montsouris (FR)
- Comprehensive Cancer Center Vienna (AT)
- Centre Georges François Leclerc (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (ES)
- Hospices Civils de Lyon (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Hôpital Européen (FR)
- Institute Cancer De La Loire Lucien Neuwirth (FR)
- CHU Dijon Bourgogne (FR)
- Hôpital Lariboisière (FR)
- Paris Cardiovascular Research Center (FR)
- Centre Hospitalier Régional Universitaire de Brest (FR)
- Postgraduate School of Molecular Medicine (PL)
- Association Francophone pour les Soins Oncologiques de Support (FR)
- UniCancer Group (FR)
- Hospital Universitario Virgen del Rocío (ES)
- Hospital Universitari Germans Trias i Pujol (ES)
- Centre Hospitalier Universitaire de Saint-Étienne (FR)
- Sotiria General Hospital (GR)
- French Clinical Research Infrastructure Network (FR)
- Geneva College (US)
- Universidad Católica de Murcia (ES)
- Hull York Medical School (GB)
- Medical University of Vienna (AT)
- Universidad de Sevilla (ES)
- Université Jean Monnet (FR)
- KU Leuven (BE)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-03-29
- DOI
- https://doi.org/10.1056/nejmoa2416112
- Citations
- 95
- Primary Topic
- Venous Thromboembolism Diagnosis and Management
- Type
- article
- Field-Weighted Citation Impact
- 177.63
Funders
- Bristol-Myers Squibb