Sodium Poly(heptazine imide)-Enabled Oxytrifluoromethylation of Alkenes for the Synthesis of α-CF<sub>3</sub> Ketones
This paper describes a NaPHI-catalyzed oxytrifluoromethylation of olefins under photoirradiation. The reaction is applicable for the synthesis of α-trifluoromethyl ketones, which could be structurally elaborated into an array of useful scaffolds. Mechanistic studies suggested that photoexcited NaPHI* could facilitate the formation of singlet <sup>1</sup>O<sub>2</sub> through an EnT process, thus enabling difunctionalization with trifluoromethyl radical and oxygen radical anion species.
Authors
- Guanyinsheng Qiu (ORCID: https://orcid.org/0000-0002-6587-8522)
- Ming Hou
- Peng Wang (ORCID: https://orcid.org/0000-0002-8234-9059)
- Chen Bao (ORCID: https://orcid.org/0000-0002-0915-0190)
- Mengying Xu (ORCID: https://orcid.org/0009-0005-8868-7939)
- Xinyu Zhu (ORCID: https://orcid.org/0009-0003-5767-1120)
Institutions
- Southwest Forestry University (CN)
- Jiaxing University (CN)
- Jiaxing Vocational Technical College (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-03-29
- DOI
- https://doi.org/10.1021/acs.joc.5c00117
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Zhejiang Province