Association of miR-126-3p, miR-1260b and miR-374a-5p with the incidence of heart failure in a population-based cohort: the Hortega Follow-Up Study
In observational analysis, miR-126-3p, miR-1260b and miR-374a-5p levels were positively associated with HF incidence. Mendelian randomization analysis supported a causal role for miR-126-3p and miR-1260b, thus suggesting a potential use as prognostic and therapeutic targets for HF prevention and control.
Authors
- Juan Carlos Martı́n-Escudero (ORCID: https://orcid.org/0000-0002-6209-6509)
- María Grau-Pérez (ORCID: https://orcid.org/0000-0003-1660-9972)
- Guillermo Pita (ORCID: https://orcid.org/0000-0003-2393-0510)
- Josep Redón (ORCID: https://orcid.org/0000-0001-8777-6773)
- María Téllez-Plaza (ORCID: https://orcid.org/0000-0002-3850-1228)
- Anna González‐Neira (ORCID: https://orcid.org/0000-0002-5421-2020)
- Zulema Rodriguez-Hernandez (ORCID: https://orcid.org/0000-0003-0720-384X)
- Raquel Cortés (ORCID: https://orcid.org/0000-0001-9607-997X)
- Ana Flores-Chova (ORCID: https://orcid.org/0000-0002-1584-5490)
- María Rosario Alonso (ORCID: https://orcid.org/0000-0002-6041-7153)
- Ana Ortega (ORCID: https://orcid.org/0000-0002-9763-0505)
- Olga Martínez-Arroyo (ORCID: https://orcid.org/0000-0001-9602-8419)
- Sílvia Pineda (ORCID: https://orcid.org/0000-0003-4017-1480)
- Pablo Fernández‐Navarro (ORCID: https://orcid.org/0000-0001-9427-2581)
- Marta Rubia-Martinez
Institutions
- Universidad Complutense de Madrid (ES)
- Instituto de Salud Carlos III (ES)
- Spanish National Cancer Research Centre (ES)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- Hospital Universitario Río Hortega (ES)
- INCLIVA Health Research Institute (ES)
- Universitat Politècnica de València (ES)
Publication Details
- Journal
- European Journal of Internal Medicine
- Published
- 2025-03-29
- DOI
- https://doi.org/10.1016/j.ejim.2025.03.022
- Citations
- 3
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- European Commission
- Generalitat Valenciana
- Ministerio de Ciencia e Innovación
- Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares
- Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición
- Instituto de Salud Carlos III
- European Regional Development Fund
- Agencia Estatal de Investigación
- European Social Fund
- FP7 Health