Harmine alleviates LPS-induced acute lung injury by inhibiting CSF3-mediated MAPK/NF-κB signaling pathway
These findings elucidated that the anti-inflammatory activity of harmine was achieved through the CSF3-mediated inactivation of the MAPK/NF-κB signaling pathway, suggesting that harmine could serve as a promising therapeutic drug for ALI and other inflammatory diseases.
Authors
- Yihui Zhai (ORCID: https://orcid.org/0000-0001-7593-5538)
- Jianbo Tong (ORCID: https://orcid.org/0000-0001-5536-2701)
- Guang Liang (ORCID: https://orcid.org/0000-0002-8278-849X)
- Zichuang Xu
- Yeying He
- Chaoyue Chen (ORCID: https://orcid.org/0000-0002-8495-2185)
- Xiaohui Zheng (ORCID: https://orcid.org/0000-0002-1307-1209)
- Kejie Chen (ORCID: https://orcid.org/0000-0001-6591-5875)
- Xiaojian Chen (ORCID: https://orcid.org/0009-0000-1851-282X)
- Meiqing Ding
Institutions
- Wenzhou Medical University (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1186/s12931-025-03196-8
- Citations
- 6
- Primary Topic
- Heme Oxygenase-1 and Carbon Monoxide
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province