An <scp>HRL</scp> ‐ <scp>SC</scp> / <scp>HIF</scp> ‐1α positive feedback loop enhances cell proliferation, migration and angiogenesis in dental pulp stem cells via <scp>PI3K</scp> / <scp>AKT</scp> signalling pathway
DPSCs modified with HRL-SC demonstrated enhanced cell viability via the PI3K/AKT signaling pathway and exhibited functional characteristics of endothelial cells, which may provide a novel strategy for the application of DPSCs in pulp regeneration.
Authors
- Yeqing Yang (ORCID: https://orcid.org/0000-0002-7931-1009)
- Ming Chen (ORCID: https://orcid.org/0000-0003-3440-0232)
- Chong Jiang (ORCID: https://orcid.org/0000-0001-8324-4112)
- Junkai Zeng (ORCID: https://orcid.org/0000-0003-4515-011X)
Institutions
- Nanfang Hospital (CN)
- Stomatology Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- International Endodontic Journal
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1111/iej.14229
- Citations
- 8
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 7.49
Funders
- National Natural Science Foundation of China